In this episode of the 'Huberman Lab' podcast, Dr. Andrew Huberman speaks with Dr. Zachary Knight about the brain's mechanisms governing hunger, satiety, and thirst. They explore the role of dopamine in cravings and dissect how genetic predisposition and environmental factors, like processed foods, contribute to obesity. Dr. Knight explains innovative pharmacological treatments, such as GLP-1 agonists for obesity and diabetes management. They discuss the role of neural circuits and hormones like leptin in hunger regulation and examine how altering food perceptions can affect eating behavior. The episode offers practical insights into maintaining a healthy relationship with food and outlines advancements in obesity and diabetes treatment.